Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vasc...
Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption
About this item
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Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Roberts syndrome (RBS) is an autosomal recessive disorder with profound growth deficiency and limb reduction caused by
ESCO2
loss-of-function variants. Here, we elucidate the pathogenesis of limb reduction in an
Esco2
fl/fl
;
Prrx1-Cre
Tg/0
mouse model using bulk- and single-cell-RNA-seq and gene co-expression network analys...
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Full title
Limb reduction in an Esco2 cohesinopathy mouse model is mediated by p53-dependent apoptosis and vascular disruption
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TN_cdi_doaj_primary_oai_doaj_org_article_3bffc4b5d1234e1f8b7e23ff349c0a99
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3bffc4b5d1234e1f8b7e23ff349c0a99
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-51328-3
