Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performan...
Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice
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Lausanne: Frontiers Research Foundation
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English
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Lausanne: Frontiers Research Foundation
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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment and no cure. Mutations in profilin 1 were identified as a cause of familial ALS in 2012. We investigated the functional impact of mutant profilin 1 expression in spinal cords during mouse development. We developed a novel mouse model with expressio...
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Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice
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TN_cdi_doaj_primary_oai_doaj_org_article_3c0e270200b2444cb6a7451db65ce18f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c0e270200b2444cb6a7451db65ce18f
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ISSN
1662-5099
E-ISSN
1662-5099
DOI
10.3389/fnmol.2019.00231
