Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis
Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Endothelial Tie2 signaling plays a pivotal role in vascular barrier maintenance at baseline and after injury. We previously demonstrated that a sharp drop in Tie2 expression observed across various murine models of critical illnesses is associated with increased vascular permeability and mortality. Matrix metalloprotease (MMP)−14-mediated Tie2 ecto...
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Full title
Identification of specific Tie2 cleavage sites and therapeutic modulation in experimental sepsis
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TN_cdi_doaj_primary_oai_doaj_org_article_3c273d0291344f799a565c38b0b7ae32
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c273d0291344f799a565c38b0b7ae32
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.59520
