Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remode...
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
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England: The Company of Biologists Ltd
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English
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England: The Company of Biologists Ltd
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Anti-angiogenic treatments against αvβ3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through αvβ3-integrin-independent mechanisms. Here, we show that suppression of β3-integrin in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration p...
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Full title
Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_3c3312f97ec54dd2b530c35f1517aff2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c3312f97ec54dd2b530c35f1517aff2
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ISSN
1754-8403,1754-8411
E-ISSN
1754-8411,1754-8403
DOI
10.1242/dmm.019927
