Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 m...
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Gain-of-function mutations in the chloride channel ClC-2 were recently described as a cause of familial hyperaldosteronism type II (FH-II). Here, we report the generation of a mouse model carrying a missense mutation homologous to the most common FH-II-associated
CLCN2
mutation. In these
Clcn2
R180Q/+
mice, adrenal morphology is norm...
Alternative Titles
Full title
Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3c3f88638ed74e3884f98fb595b7139e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c3f88638ed74e3884f98fb595b7139e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13033-4
