Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in M...
Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
The development of an anti-drug antibody (ADA)-tolerant pharmacokinetic (PK) assay is important when the drug exposure is irrelevant to toxicity in the presence of ADA. We aimed to develop and validate an ADA-tolerant assay for an exatecan-based antibody-drug conjugate (ADC) in monkey plasma.
The assay tolerated 5.00 µg/mL of ADA at 12 µg/mL of...
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Full title
Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma
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TN_cdi_doaj_primary_oai_doaj_org_article_3c75d75cd3584f4da028a319053008f7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c75d75cd3584f4da028a319053008f7
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ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules29030572
