Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells
Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells
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Publisher
London: Springer Science and Business Media LLC
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Language
English
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Publisher
London: Springer Science and Business Media LLC
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Contents
Thiopurines, such as 6-mercaptopurine (6-MP), are widely used as cytotoxic agents and immunosuppressants for leukemia and autoimmune or inflammatory diseases. A nonsynonymous single nucleotide polymorphism (p.Arg139Cys; R139C) of the nucleoside diphosphate-linked moiety X-type motif 15 (
NUDT15
) gene causes the loss of thiopurine detoxificat...
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Full title
Loss of Nudt15 thiopurine detoxification increases direct DNA damage in hematopoietic stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_3c96629815534cc8a1d0fa30ceebdd8c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3c96629815534cc8a1d0fa30ceebdd8c
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-38952-7
