Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors
Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors
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England: Taylor & Francis Ltd
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English
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England: Taylor & Francis Ltd
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Inhibiting apoptosis signal regulated kinase 1 (ASK1) is an attractive strategy for treating diseases such as non-alcoholic steatohepatitis and multiple sclerosis. Here, we report the discovery of a dibromo substituted quinoxaline fragment containing
as an effective small-molecule inhibitor of ASK1, with an IC
value of 30.17 nM. In addition,...
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Full title
Synthesis and biological evaluation of quinoxaline derivatives as ASK1 inhibitors
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TN_cdi_doaj_primary_oai_doaj_org_article_3cae62aaeca548e1aca3f8b16fd97d34
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3cae62aaeca548e1aca3f8b16fd97d34
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ISSN
1475-6366,1475-6374
E-ISSN
1475-6374
DOI
10.1080/14756366.2024.2414382
