Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE6 cells, SARS-CoV-2 may mutate or delete the multibasic cleavage site (MBCS) in the spike protein. P...
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Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
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TN_cdi_doaj_primary_oai_doaj_org_article_3d0c2b13478f4404ae22e956acd8b062
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d0c2b13478f4404ae22e956acd8b062
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.66815
