Cerebral small vessel disease genomics and its implications across the lifespan
Cerebral small vessel disease genomics and its implications across the lifespan
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Author / Creator
International Headache Genomics Consortium (IHGC) , International Network against Thrombosis (INVENT) Consortium , Sargurupremraj, Muralidharan , Suzuki, Hideaki , Jian, Xueqiu , Sarnowski, Chloé , Evans, Tavia E. , Eiriksdottir, Gudny , Sakaue, Saori , Terzikhan, Natalie , Zhao, Wei , Armstrong, Nicola J. , Yanek, Lisa R. , Kumar, Rajan B. , van den Akker, Erik B. , McWhirter, Rebekah E. , Trompet, Stella , Mishra, Aniket , Saba, Yasaman , Satizabal, Claudia L. , Beaudet, Gregory , Petit, Laurent , Tsuchida, Ami , Schilling, Sabrina , Sigurdsson, Sigurdur , Lewis, Cora E. , Lopez, Oscar L. , Smith, Jennifer A. , Valdés Hernández, Maria C. , van der Grond, Jeroen , Wright, Margaret J. , Knol, Maria J. , Thomson, Russell J. , Le Grand, Quentin , Duperron, Marie-Gabrielle , Smith, Albert V. , Schreiner, Pamela J. , Evans, Denis A. , Rotter, Jerome I. , Beiser, Alexa S. , Maniega, Susana Muñoz , Beekman, Marian , Trollor, Julian , Stott, David J. , Vernooij, Meike W. , Wittfeld, Katharina , Niessen, Wiro J. , Soumaré, Aicha , Sidney, Stephen , Turner, Stephen T. , Davies, Gail , Thalamuthu, Anbupalam , Völker, Uwe , van Buchem, Mark A. , Dupuis, Josée , Bastin, Mark E. , Teumer, Alexander , Amouyel, Philippe , Kwok, John B. , Bülow, Robin , Deary, Ian J. , Schofield, Peter R. , Brodaty, Henry , Jiang, Jiyang , Tabara, Yasuharu , Setoh, Kazuya , Miyamoto, Susumu , Yoshida, Kazumichi , Nagata, Manabu , Matsuda, Fumihiko , Psaty, Bruce M. , Bennett, David A. , De Jager, Philip L. , Mosley, Thomas H. , Sachdev, Perminder S. , Schmidt, Reinhold , Evangelou, Evangelos , Trégouët, David-Alexandre , Ikram, Mohammad A. , DeCarli, Charles , Srikanth, Velandai K. , Jukema, J. Wouter , Slagboom, Eline P. , Kardia, Sharon L. R. , Okada, Yukinori , Mazoyer, Bernard , Wardlaw, Joanna M. , Nyquist, Paul A. , Mather, Karen A. , Grabe, Hans J. , Schmidt, Helena , Van Duijn, Cornelia M. , Gudnason, Vilmundur , Longstreth, William T. , Launer, Lenore J. , Lathrop, Mark , Seshadri, Sudha , Tzourio, Christophe , Adams, Hieab H. , Matthews, Paul M. , Fornage, Myriam and Debette, Stéphanie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vessel disease (SVD), hypertension being the main known risk factor. Here, we identify 27 genome-wide loci for WMH-volume in a cohort of 50,970 older individuals, accounting for modification/confounding by hypertension. Aggregated WMH risk variants were...
Alternative Titles
Full title
Cerebral small vessel disease genomics and its implications across the lifespan
Authors, Artists and Contributors
Author / Creator
International Network against Thrombosis (INVENT) Consortium
Sargurupremraj, Muralidharan
Suzuki, Hideaki
Jian, Xueqiu
Sarnowski, Chloé
Evans, Tavia E.
Eiriksdottir, Gudny
Sakaue, Saori
Terzikhan, Natalie
Zhao, Wei
Armstrong, Nicola J.
Yanek, Lisa R.
Kumar, Rajan B.
van den Akker, Erik B.
McWhirter, Rebekah E.
Trompet, Stella
Mishra, Aniket
Saba, Yasaman
Satizabal, Claudia L.
Beaudet, Gregory
Petit, Laurent
Tsuchida, Ami
Schilling, Sabrina
Sigurdsson, Sigurdur
Lewis, Cora E.
Lopez, Oscar L.
Smith, Jennifer A.
Valdés Hernández, Maria C.
van der Grond, Jeroen
Wright, Margaret J.
Knol, Maria J.
Thomson, Russell J.
Le Grand, Quentin
Duperron, Marie-Gabrielle
Smith, Albert V.
Schreiner, Pamela J.
Evans, Denis A.
Rotter, Jerome I.
Beiser, Alexa S.
Maniega, Susana Muñoz
Beekman, Marian
Trollor, Julian
Stott, David J.
Vernooij, Meike W.
Wittfeld, Katharina
Niessen, Wiro J.
Soumaré, Aicha
Sidney, Stephen
Turner, Stephen T.
Davies, Gail
Thalamuthu, Anbupalam
Völker, Uwe
van Buchem, Mark A.
Dupuis, Josée
Bastin, Mark E.
Teumer, Alexander
Amouyel, Philippe
Kwok, John B.
Bülow, Robin
Deary, Ian J.
Schofield, Peter R.
Brodaty, Henry
Jiang, Jiyang
Tabara, Yasuharu
Setoh, Kazuya
Miyamoto, Susumu
Yoshida, Kazumichi
Nagata, Manabu
Matsuda, Fumihiko
Psaty, Bruce M.
Bennett, David A.
De Jager, Philip L.
Mosley, Thomas H.
Sachdev, Perminder S.
Schmidt, Reinhold
Evangelou, Evangelos
Trégouët, David-Alexandre
Ikram, Mohammad A.
DeCarli, Charles
Srikanth, Velandai K.
Jukema, J. Wouter
Slagboom, Eline P.
Kardia, Sharon L. R.
Okada, Yukinori
Mazoyer, Bernard
Wardlaw, Joanna M.
Nyquist, Paul A.
Mather, Karen A.
Grabe, Hans J.
Schmidt, Helena
Van Duijn, Cornelia M.
Gudnason, Vilmundur
Longstreth, William T.
Launer, Lenore J.
Lathrop, Mark
Seshadri, Sudha
Tzourio, Christophe
Adams, Hieab H.
Matthews, Paul M.
Fornage, Myriam
Debette, Stéphanie
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3d0e1a5389ab4d9387592a6316f6a661
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d0e1a5389ab4d9387592a6316f6a661
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19111-2
