Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation
Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Abdominal aortic aneurysm (AAA) is a complex disease which is incompletely accounted for. Basement membrane (BM) Collagen IV (COL4A1/A2) is abundant in the artery wall, and several lines of evidence indicate a protective role of baseline COL4A1/A2 in AAA development. Using
Col4a1/a2
hemizygous knockout mice (
Col4a1/a2
+
/−
, 129S...
Alternative Titles
Full title
Basement membrane collagen IV deficiency promotes abdominal aortic aneurysm formation
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TN_cdi_doaj_primary_oai_doaj_org_article_3d1b5c247947475dacbe108ba6ec5da2
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d1b5c247947475dacbe108ba6ec5da2
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-92303-y
