Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative ho...
Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative homeostasis and imbalanced dNTP pools
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Author / Creator
Zhang, Xiao , Di, Yuchang , Zhang, Yu , Hu, Youwei , Chi, Mingzhe , Kang, Jian , Zheng, Yuqing , Wang, Hengyu , Wang, Yu , Chen, Jiazhen and Zhang, Xuelian
Publisher
United States: Taylor & Francis
Journal title
Language
English
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Publisher
United States: Taylor & Francis
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Contents
Ribonucleotide reductase (RNR) catalyzes the synthesis of four deoxyribonucleoside triphosphates (dNTPs), which are essential for DNA replication. Although dNTP imbalances reduce replication fidelity and elevate mutation rates, the impact of RNR dysfunction on Mycobacterium tuberculosis (Mtb) physiology and drug resistance remains unknown. Here, we...
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Full title
Hypermutability of Mycolicibacterium smegmatis due to ribonucleotide reductase-mediated oxidative homeostasis and imbalanced dNTP pools
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TN_cdi_doaj_primary_oai_doaj_org_article_3d2c6df8f9364c46ad957283f175a1ae
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d2c6df8f9364c46ad957283f175a1ae
Other Identifiers
ISSN
2222-1751
E-ISSN
2222-1751
DOI
10.1080/22221751.2025.2480698
