sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association...
sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
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Publisher
England: BioMed Central
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Language
English
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Publisher
England: BioMed Central
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Scope and Contents
Contents
Meta-analysis has been established as an effective approach to combining summary statistics of several genome-wide association studies (GWAS). However, the accuracy of meta-analysis can be attenuated in the presence of cross-study heterogeneity. We present
sPLINK
, a hybrid federated and user-friendly tool, which performs privacy-aware GWAS on distributed datasets while preserving the accuracy of the results.
sPLINK
is robust against heterogeneous distributions of data across cohorts while meta-analysis considerably loses accuracy in such scenarios.
sPLINK
achieves practical runtime and acceptable network usage for chi-square and linear/logistic regression tests.
sPLINK
is available at
https://exbio.wzw.tum.de/splink
....
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Full title
sPLINK: a hybrid federated tool as a robust alternative to meta-analysis in genome-wide association studies
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3d896a9b432e4884b5b3e0f48567d7c7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3d896a9b432e4884b5b3e0f48567d7c7
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02562-1
