Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Prom...
Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
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Author / Creator
Li, Yingze , Fang, Guojian , Cao, Wei , Yuan, Jiali , Song, Shuai , Peng, Hong , Wang, Yuepeng and Wang, Qunshan
Publisher
Macclesfield: Dove Medical Press Limited
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Language
English
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Publisher
Macclesfield: Dove Medical Press Limited
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Background: In most cell types, replicative senescence (RS) is supposed to be a principle causative factor for aging. Atrial fibrosis, pathologically characterized by proliferation of atrial fibroblasts (AFs) and excessive accumulation of extracellular matrix proteins, is the most common substrate of atrial fibrillation (Afib) in the elderly. Howev...
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Full title
Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
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TN_cdi_doaj_primary_oai_doaj_org_article_3e0c570a406746bbace1c7f9f055b3a4
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e0c570a406746bbace1c7f9f055b3a4
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ISSN
1178-7031
E-ISSN
1178-7031
DOI
10.2147/JIR.S374951
