Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats wi...
Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency
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Author / Creator
Wu, Mian , Ma, Yiwen , Chen, Xiaoting , Liang, Nan , Qu, Shen and Chen, Haibing
Publisher
England: The Company of Biologists Ltd
Journal title
Language
English
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Publisher
England: The Company of Biologists Ltd
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Contents
Epidemiological research has shown that elevated serum urate concentration is a risk factor for the development of kidney disease; however, the mechanisms underlying this process have not yet been elucidated. To examine the role of urate in the kidney, we used Wistar rats to functionally disrupt expression of urate oxidase (UOX) by using the CRISPR...
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Full title
Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency
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TN_cdi_doaj_primary_oai_doaj_org_article_3e39c6ba5eca4ad886a30120e9e071f6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e39c6ba5eca4ad886a30120e9e071f6
Other Identifiers
ISSN
1754-8403
E-ISSN
1754-8411
DOI
10.1242/dmm.048041
