How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
The Nef protein of HIV-1 downregulates the cell surface co-receptor CD4 by hijacking the clathrin adaptor complex AP-2. The structural basis for the hijacking of AP-2 by Nef is revealed by a 2.9 Å crystal structure of Nef bound to the α and σ2 subunits of AP-2. Nef binds to AP-2 via its central loop (residues 149–179) and its core. The determinants...
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Full title
How HIV-1 Nef hijacks the AP-2 clathrin adaptor to downregulate CD4
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TN_cdi_doaj_primary_oai_doaj_org_article_3e693b9f31044506b87c9c3e21b63cac
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e693b9f31044506b87c9c3e21b63cac
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.01754
