Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert...
Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations
About this item
Full title
Author / Creator
Ajore, Ram , Raiser, David , McConkey, Marie , Jöud, Magnus , Boidol, Bernd , Mar, Brenton , Saksena, Gordon , Weinstock, David M , Armstrong, Scott , Ellis, Steven R , Ebert, Benjamin L , Nilsson, Björn , Faculty of Medicine , Medicinska fakulteten , Lund University , Institutionen för laboratoriemedicin , Department of Laboratory Medicine , Division of Hematology and Clinical Immunology , Avdelningen för hematologi och klinisk immunologi , Hematogenomics and Lunds universitet
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large‐scale analysis of cancer genome data to examine the frequency and selective pressure of RPG lesions across hum...
Alternative Titles
Full title
Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations
Authors, Artists and Contributors
Author / Creator
Raiser, David
McConkey, Marie
Jöud, Magnus
Boidol, Bernd
Mar, Brenton
Saksena, Gordon
Weinstock, David M
Armstrong, Scott
Ellis, Steven R
Ebert, Benjamin L
Nilsson, Björn
Faculty of Medicine
Medicinska fakulteten
Lund University
Institutionen för laboratoriemedicin
Department of Laboratory Medicine
Division of Hematology and Clinical Immunology
Avdelningen för hematologi och klinisk immunologi
Hematogenomics
Lunds universitet
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3e6cbff888654a0ea0a66eb8b06bbc66
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e6cbff888654a0ea0a66eb8b06bbc66
Other Identifiers
ISSN
1757-4676,1757-4684
E-ISSN
1757-4684
DOI
10.15252/emmm.201606660
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