ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The accumulation of damaged mitochondria causes the death of dopaminergic neurons. The Parkin-mediated mitophagy pathway functions to remove these mitochondria from cells. Targeting this pathway represents a therapeutic strategy for several neurodegenerative diseases, most notably Parkinson’s disease. We describe a discovery pipeline to identify sm...
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Full title
ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_3e89b2ca7aa044dba87795668f0519b1
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e89b2ca7aa044dba87795668f0519b1
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13781-3
