mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glyc...
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
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Author / Creator
Liu, Rui , Zeng, Lin-Wen , Gong, Rong , Yuan, Fanen , Shu, Hong-Bing and Li, Shu
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Glycine decarboxylase (GLDC) is a key enzyme of glycine cleavage system that converts glycine into one-carbon units. GLDC is commonly up-regulated and plays important roles in many human cancers. Whether and how GLDC is regulated by post-translational modifications is unknown. Here we report that mechanistic target of rapamycin complex 1 (mTORC1) s...
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Full title
mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_3e8e2ec8a90b413e8b695cd802a92e8f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e8e2ec8a90b413e8b695cd802a92e8f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-24321-3
