Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lym...
Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study
About this item
Full title
Author / Creator
Schaff, Lauren R. , Lobbous, Mina , Carlow, Dean , Schofield, Ryan , Gavrilovic, Igor T. , Miller, Alexandra M. , Stone, Jacqueline B. , Piotrowski, Anna F. , Sener, Ugur , Skakodub, Anna , Acosta, Edward P. , Ryan, Kevin J. , Mellinghoff, Ingo K. , DeAngelis, Lisa M. , Nabors, Louis B. and Grommes, Christian
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
High-dose methotrexate (HD-MTX) has broad use in the treatment of central nervous system (CNS) malignancies but confers significant toxicity without inpatient hydration and monitoring. Glucarpidase is a bacterial recombinant enzyme dosed at 50 units (u)/kg, resulting in rapid systemic MTX clearance. The aim of this study was to demonstrate feasibil...
Alternative Titles
Full title
Routine use of low-dose glucarpidase following high-dose methotrexate in adult patients with CNS lymphoma: an open-label, multi-center phase I study
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3e9f2e48ef674472afa6c947189513cd
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3e9f2e48ef674472afa6c947189513cd
Other Identifiers
ISSN
1471-2407
E-ISSN
1471-2407
DOI
10.1186/s12885-021-09164-x
