Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
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Author / Creator
Hendrix, Sebastian , Kingma, Jenina , Ottenhoff, Roelof , Valiloo, Masoud , Svecla, Monika , Zijlstra, Lobke F. , Sachdev, Vinay , Kovac, Kristina , Levels, Johannes H. M. , Jongejan, Aldo , de Boer, Jan F. , Kuipers, Folkert , Rimbert, Antoine , Norata, Giuseppe D. , Loregger, Anke and Zelcer, Noam
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified SPRING as a post-transcriptional regulator of SREBP activation. Constitutive or inducible global ablation of
Spring
in mice is not tolerated, and we therefore develop liver-specific
Spr...
Alternative Titles
Full title
Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3f5880a3788d4aad95e74419033308ec
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3f5880a3788d4aad95e74419033308ec
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40943-1
