Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcription...
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
About this item
Full title
Author / Creator
Xiong, Lei , Wu, Feng , Wu, Qiong , Xu, Liangliang , Cheung, Otto K. , Kang, Wei , Mok, Myth T. , Szeto, Lemuel L. M. , Lun, Cheuk-Yin , Lung, Raymond W. , Zhang, Jinglin , Yu, Ken H. , Lee, Sau-Dan , Huang, Guangcun , Wang, Chiou-Miin , Liu, Joseph , Yu, Zhuo , Yu, Dae-Yeul , Chou, Jian-Liang , Huang, Wan-Hong , Feng, Bo , Cheung, Yue-Sun , Lai, Paul B. , Tan, Patrick , Wong, Nathalie , Chan, Michael W. , Huang, Tim H. , Yip, Kevin Y. , Cheng, Alfred S. and To, Ka-Fai
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Hepatocellular carcinomas (HCC) exhibit distinct promoter hypermethylation patterns, but the epigenetic regulation and function of transcriptional enhancers remain unclear. Here, our affinity- and bisulfite-based whole-genome sequencing analyses reveal global enhancer hypomethylation in human HCCs. Integrative epigenomic characterization further pi...
Alternative Titles
Full title
Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming
Authors, Artists and Contributors
Author / Creator
Wu, Feng
Wu, Qiong
Xu, Liangliang
Cheung, Otto K.
Kang, Wei
Mok, Myth T.
Szeto, Lemuel L. M.
Lun, Cheuk-Yin
Lung, Raymond W.
Zhang, Jinglin
Yu, Ken H.
Lee, Sau-Dan
Huang, Guangcun
Wang, Chiou-Miin
Liu, Joseph
Yu, Zhuo
Yu, Dae-Yeul
Chou, Jian-Liang
Huang, Wan-Hong
Feng, Bo
Cheung, Yue-Sun
Lai, Paul B.
Tan, Patrick
Wong, Nathalie
Chan, Michael W.
Huang, Tim H.
Yip, Kevin Y.
Cheng, Alfred S.
To, Ka-Fai
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3f6c3461a5c841138bb59978799a70b5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3f6c3461a5c841138bb59978799a70b5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-08245-z
