M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposu...
M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-κB signaling axis
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Author / Creator
Fan, Chunyang , Wang, Wei , Yu, Zilin , Wang, Jiale , Xu, Wei , Ji, Zhongwei , He, Wei , Hua, Di , Wang, Wentao , Yao, Linye , Deng, Yongkang , Geng, Dechun , Wu, Xiexing and Mao, Haiqing
Publisher
England: BMC
Journal title
Language
English
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Publication information
Publisher
England: BMC
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Scope and Contents
Contents
Intervertebral disc degeneration (IVDD) is the primary factor contributing to low back pain (LBP). Unlike elderly patients, many young IVDD patients usually have a history of trauma or long-term abnormal stress, which may lead to local inflammatory reaction causing by immune cells, and ultimately accelerates degeneration. Research has shown the sig...
Alternative Titles
Full title
M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-κB signaling axis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3fa3c22bfe5844cfb73a1968b14d6348
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3fa3c22bfe5844cfb73a1968b14d6348
Other Identifiers
ISSN
1477-3155
E-ISSN
1477-3155
DOI
10.1186/s12951-024-02556-8
