Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis
Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis
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United States: John Wiley & Sons, Inc
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English
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United States: John Wiley & Sons, Inc
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In humans, germline TP53 mutations predispose carriers to a wide spectrum of cancers, which is known as Li–Fraumeni syndrome (LFS). To date, the association of melanomas with LFS remains unestablished. No melanomas have been reported in any P53‐modified mouse models either. In this study, we show that targeted disruption of P53 at the DNA‐binding d...
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Disruption of tp53 leads to cutaneous nevus and melanoma formation in Xenopus tropicalis
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TN_cdi_doaj_primary_oai_doaj_org_article_3faa884090d843029c628043a39f4bd0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3faa884090d843029c628043a39f4bd0
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ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.13301
