TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelia...
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
About this item
Full title
Author / Creator
Woznicki, Jerzy A. , Saini, Nisha , Flood, Peter , Rajaram, Subhasree , Lee, Ciaran M. , Stamou, Panagiota , Skowyra, Agnieszka , Bustamante-Garrido, Milan , Regazzoni, Karine , Crawford, Nyree , McDade, Simon S. , Longley, Daniel B. , Aza-Blanc, Pedro , Shanahan, Fergus , Zulquernain, Syed A. , McCarthy, Jane , Melgar, Silvia , McRae, Bradford L. and Nally, Ken
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Rewiring of host cytokine networks is a key feature of inflammatory bowel diseases (IBD) such as Crohn’s disease (CD). Th1-type cytokines—IFN-γ and TNF-α—occupy critical nodes within these networks and both are associated with disruption of gut epithelial barrier function. This may be due to their ability to synergistically trigger the death of int...
Alternative Titles
Full title
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells
Authors, Artists and Contributors
Author / Creator
Saini, Nisha
Flood, Peter
Rajaram, Subhasree
Lee, Ciaran M.
Stamou, Panagiota
Skowyra, Agnieszka
Bustamante-Garrido, Milan
Regazzoni, Karine
Crawford, Nyree
McDade, Simon S.
Longley, Daniel B.
Aza-Blanc, Pedro
Shanahan, Fergus
Zulquernain, Syed A.
McCarthy, Jane
Melgar, Silvia
McRae, Bradford L.
Nally, Ken
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3fd851ad37fa451687518ec09ff3247a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3fd851ad37fa451687518ec09ff3247a
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-04151-3
