An integrated machine learning approach delineates an entropic expansion mechanism for the binding o...
An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein
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England: eLife Sciences Publications, Ltd
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English
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England: eLife Sciences Publications, Ltd
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The mis-folding and aggregation of intrinsically disordered proteins (IDPs) such as α-synuclein (αS) underlie the pathogenesis of various neurodegenerative disorders. However, targeting αS with small molecules faces challenges due to the lack of defined ligand-binding pockets in its disordered structure. Here, we implement a deep artificial neural...
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An integrated machine learning approach delineates an entropic expansion mechanism for the binding of a small molecule to α-synuclein
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TN_cdi_doaj_primary_oai_doaj_org_article_3fdc90b371e34eb682e9f28a9d083d88
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3fdc90b371e34eb682e9f28a9d083d88
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.97709
