Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in...
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Single-strand breaks (SSBs) represent the major form of DNA damage, yet techniques to map these lesions genome-wide with nucleotide-level precision are limited. Here, we present a method, termed SSiNGLe, and demonstrate its utility to explore the distribution and dynamic changes in genome-wide SSBs in response to different biological and environmen...
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Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells
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TN_cdi_doaj_primary_oai_doaj_org_article_3feb697ac4a94e7e834ab5f5f7ce2e50
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3feb697ac4a94e7e834ab5f5f7ce2e50
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13602-7
