A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by...
A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Regulatory T cells (Treg cells) inhibit effector T cells and maintain immune system homeostasis. Treg cell maturation in peripheral sites requires inhibition of protein kinase mTORC1 and TGF-beta-1 (TGF-beta). While Treg cell maturation requires protein synthesis, mTORC1 inhibition downregulates it, leaving unanswered how Treg cells achieve essenti...
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A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells
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TN_cdi_doaj_primary_oai_doaj_org_article_4045d5672d59446ca9d6d5c7a59cca09
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4045d5672d59446ca9d6d5c7a59cca09
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27087-w
