NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma
NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma
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Author / Creator
Xia, Jiliang , He, Yanjuan , Meng, Bin , Chen, Shilian , Zhang, Jingyu , Wu, Xuan , Zhu, Yinghong , Shen, Yi , Feng, Xiangling , Guan, Yongjun , Kuang, Chunmei , Guo, Jiaojiao , Lei, Qian , Wu, Yangbowen , An, Gang , Li, Guancheng , Qiu, Lugui , Zhan, Fenghuang and Zhou, Wen
Publisher
United States: John Wiley & Sons, Inc
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English
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Publisher
United States: John Wiley & Sons, Inc
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Contents
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high NEK2 confers inferior survival in multiple myeloma (MM); thus, a better understanding of the mechanisms by which NEK2 induces drug resistance in MM is required. In this study, we discovered that NEK2 enhances MM cell autophagy, and a combination of...
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Full title
NEK2 induces autophagy‐mediated bortezomib resistance by stabilizing Beclin‐1 in multiple myeloma
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TN_cdi_doaj_primary_oai_doaj_org_article_40ca287c80a94d59b45c6f39103fa18a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_40ca287c80a94d59b45c6f39103fa18a
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ISSN
1574-7891
E-ISSN
1878-0261
DOI
10.1002/1878-0261.12641
