High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 ex...
High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The spinocerebellar ataxias (SCA) comprise a group of inherited neurodegenerative diseases. SCA3 is the most common form, caused by the expansion of CAG repeats within the ataxin 3 (
ATXN3
) gene. The mutation results in the expression of an abnormal protein, containing long polyglutamine (polyQ) stretches. The polyQ stretch confers a toxic g...
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High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression
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TN_cdi_doaj_primary_oai_doaj_org_article_40e815e16121449ca8b2494f5f06e67c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_40e815e16121449ca8b2494f5f06e67c
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-41192-4
