Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell l...
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer
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Author / Creator
Long, Kaili , Gu, Lili , Li, Lulu , Zhang, Ziyu , Li, Enjie , Zhang, Yilan , He, Lingfeng , Pan, Feiyan , Guo, Zhigang and Hu, Zhigang
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Apurinic/apyrimidinic endonuclease 1 (APE1) plays a critical role in the base excision repair (BER) pathway, which is responsible for the excision of apurinic sites (AP sites). In non-small cell lung cancer (NSCLC), APE1 is highly expressed and associated with poor patient prognosis. The suppression of APE1 could lead to the accumulation of unrepai...
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Full title
Small-molecule inhibition of APE1 induces apoptosis, pyroptosis, and necroptosis in non-small cell lung cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_4145d57ce11847838a8d1d3f9021e9f6
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4145d57ce11847838a8d1d3f9021e9f6
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03804-7
