Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
About this item
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Author / Creator
De Genst, Erwin , Foo, Kylie S. , Xiao, Yao , Rohner, Eduarde , de Vries, Emma , Sohlmér, Jesper , Witman, Nevin , Hidalgo, Alejandro , Kolstad, Terje R. S. , Louch, William E. , Pehrsson, Susanne , Park, Andrew , Ikeda, Yasuhiro , Li, Xidan , Mayr, Lorenz M. , Wickson, Kate , Jennbacken, Karin , Hansson, Kenny , Fritsche-Danielson, Regina , Hunt, James and Chien, Kenneth R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The dysregulated physical interaction between two intracellular membrane proteins, the sarco/endoplasmic reticulum Ca
2+
ATPase and its reversible inhibitor phospholamban, induces heart failure by inhibiting calcium cycling. While phospholamban is a bona-fide therapeutic target, approaches to selectively inhibit this protein remain elusive. H...
Alternative Titles
Full title
Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
Authors, Artists and Contributors
Author / Creator
Foo, Kylie S.
Xiao, Yao
Rohner, Eduarde
de Vries, Emma
Sohlmér, Jesper
Witman, Nevin
Hidalgo, Alejandro
Kolstad, Terje R. S.
Louch, William E.
Pehrsson, Susanne
Park, Andrew
Ikeda, Yasuhiro
Li, Xidan
Mayr, Lorenz M.
Wickson, Kate
Jennbacken, Karin
Hansson, Kenny
Fritsche-Danielson, Regina
Hunt, James
Chien, Kenneth R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_41820d2e39ea4787978141037e15dc1e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_41820d2e39ea4787978141037e15dc1e
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29703-9
