OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Linear ubiquitination regulates inflammatory and cell death signalling. Deficiency of the linear ubiquitin chain-specific deubiquitinase, OTULIN, causes OTULIN-related autoinflammatory syndrome (ORAS), a systemic inflammatory pathology affecting multiple organs including the skin. Here we show that mice with epidermis-specific OTULIN deficiency (OT...
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Full title
OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice
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TN_cdi_doaj_primary_oai_doaj_org_article_4192568021a0480cba718d68204be796
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4192568021a0480cba718d68204be796
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25945-1
