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Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVI...

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVI...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_41b097963d3a4f95bc528fc71d41ad9c

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19

About this item

Full title

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19

Publisher

England: BioMed Central Ltd

Journal title

Cell & bioscience, 2024-09, Vol.14 (1), p.115-25, Article 115

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial role in both cancer cell survival and stress adaptation. GRP78 is also upregulated during SARS-CoV-2 infection and acts as...

Alternative Titles

Full title

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_41b097963d3a4f95bc528fc71d41ad9c

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_41b097963d3a4f95bc528fc71d41ad9c

Other Identifiers

ISSN

2045-3701

E-ISSN

2045-3701

DOI

10.1186/s13578-024-01297-3

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