In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice
In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Hemochromatosis is one of the most common inherited metabolic diseases among white populations and predominantly originates from a homozygous C282Y mutation in the
HFE
gene. The G > A transition at position c.845 of the gene causes misfolding of the HFE protein, ultimately resulting in its absence at the cell membrane. Consequently, the lack...
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In vivo adenine base editing reverts C282Y and improves iron metabolism in hemochromatosis mice
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TN_cdi_doaj_primary_oai_doaj_org_article_41baa3360d14427b871c13b614264a6d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_41baa3360d14427b871c13b614264a6d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-32906-9
