CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intri...
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
About this item
Full title
Author / Creator
Schneider, Enja , Winzer, Riekje , Rissiek, Anne , Ricklefs, Isabell , Meyer-Schwesinger, Catherine , Ricklefs, Franz L. , Bauche, Andreas , Behrends, Jochen , Reimer, Rudolph , Brenna, Santra , Wasielewski, Hauke , Lauten, Melchior , Rissiek, Björn , Puig, Berta , Cortesi, Filippo , Magnus, Tim , Fliegert, Ralf , Müller, Christa E. , Gagliani, Nicola and Tolosa, Eva
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Immune cells at sites of inflammation are continuously activated by local antigens and cytokines, and regulatory mechanisms must be enacted to control inflammation. The stepwise hydrolysis of extracellular ATP by ectonucleotidases CD39 and CD73 generates adenosine, a potent immune suppressor. Here we report that human effector CD8 T cells contribut...
Alternative Titles
Full title
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression
Authors, Artists and Contributors
Author / Creator
Winzer, Riekje
Rissiek, Anne
Ricklefs, Isabell
Meyer-Schwesinger, Catherine
Ricklefs, Franz L.
Bauche, Andreas
Behrends, Jochen
Reimer, Rudolph
Brenna, Santra
Wasielewski, Hauke
Lauten, Melchior
Rissiek, Björn
Puig, Berta
Cortesi, Filippo
Magnus, Tim
Fliegert, Ralf
Müller, Christa E.
Gagliani, Nicola
Tolosa, Eva
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_423c6b103e9d4f51bf3e93a6880c1a59
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_423c6b103e9d4f51bf3e93a6880c1a59
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26134-w
