DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
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Author / Creator
Sun, Xiaona , Liu, Ting , Zhao, Jun , Xia, Hansong , Xie, Jun , Guo, Yu , Zhong, Li , Li, Mi , Yang, Qing , Peng, Cheng , Rouvet, Isabelle , Belot, Alexandre , Shu, Hong-Bing , Feng, Pinghui and Zhang, Junjie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Upon sensing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial defenses and certain autoimmune diseases. Missense mutations of
PRKDC
encoding the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) are associated with autoimmune diseases, yet how DNA-PK deficiency leads to increased imm...
Alternative Titles
Full title
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4244008ca6074117babe9a1796cb68c8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4244008ca6074117babe9a1796cb68c8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19941-0
