Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Npl4 is likely to be the most upstream factor recognizing Lys48-linked polyubiquitylated substrates in the proteasomal degradation pathway in yeast. Along with Ufd1, Npl4 forms a heterodimer (UN), and functions as a cofactor for the Cdc48 ATPase. Here, we report the crystal structures of yeast Npl4 in complex with Lys48-linked diubiquitin and with...
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Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4
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TN_cdi_doaj_primary_oai_doaj_org_article_4244723ac5d244baa41f569db4a6c956
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4244723ac5d244baa41f569db4a6c956
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13697-y
