Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
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Author / Creator
Filtjens, Jessica , Roger, Anais , Quatrini, Linda , Wieduwild, Elisabeth , Gouilly, Jordi , Hoeffel, Guillaume , Rossignol, Rafaëlle , Daher, Clara , Debroas, Guilhaume , Henri, Sandrine , Jones, Claerwen M. , Malissen, Bernard , Mackay, Laura K. , Moqrich, Aziz , Carbone, Francis R. and Ugolini, Sophie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Host protection against cutaneous herpes simplex virus 1 (HSV-1) infection relies on the induction of a robust adaptive immune response. Here, we show that Nav
1.8
+
sensory neurons, which are involved in pain perception, control the magnitude of CD8 T cell priming and expansion in HSV-1-infected mice. The ablation of Nav
1.8
-expres...
Alternative Titles
Full title
Nociceptive sensory neurons promote CD8 T cell responses to HSV-1 infection
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TN_cdi_doaj_primary_oai_doaj_org_article_42a3ec0604df491d8f51a1b9be9121c7
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_42a3ec0604df491d8f51a1b9be9121c7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22841-6
