Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondria...
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
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Author / Creator
Whiteley, Alexandra M , Prado, Miguel A , Peng, Ivan , Abbas, Alexander R , Haley, Benjamin , Paulo, Joao A , Reichelt, Mike , Katakam, Anand , Sagolla, Meredith , Modrusan, Zora , Lee, Dong Yun , Roose-Girma, Merone , Kirkpatrick, Donald S , McKenzie, Brent S , Gygi, Steven P , Finley, Daniel and Brown, Eric J
Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation. We carried out a proteomic analysis of a B cell lymphoma-derived cell line, BJAB, that requires UBQLN1 for survival to identify UBQLN1 client proteins. When UBQLN1 expression was a...
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Full title
Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_42dd1cf6a73646cb83c9e311eb97172a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_42dd1cf6a73646cb83c9e311eb97172a
Other Identifiers
ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.26435
