Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells t...
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Local interactions between cancer cells and stroma can produce systemic effects on distant organs to govern cancer progression. Here we show that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal cancer cells instigates VEGFR1-positive bone marrow cells in the tumour macroenvironment to form pre-metastatic niches at dis...
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Full title
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
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TN_cdi_doaj_primary_oai_doaj_org_article_42f1fba27d344814905048b4a4333e89
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_42f1fba27d344814905048b4a4333e89
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms14399
