ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
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Xiao, Xiangling , Shi, Jie , He, Chuan , Bu, Xia , Sun, Yishuang , Gao, Minling , Xiang, Bolin , Xiong, Wenjun , Dai, Panpan , Mao, Qi , Xing, Xixin , Yao, Yingmeng , Yu, Haisheng , Xu, Gaoshan , Li, Siqi , Ren, Yan , Chen, Baoxiang , Jiang, Congqing , Meng, Geng , Lee, Yu-Ru , Wei, Wenyi , Freeman, Gordon J. , Xie, Conghua and Zhang, Jinfang
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The programmed cell death protein 1 (PD-1) is an inhibitory receptor on T cells and plays an important role in promoting cancer immune evasion. While ubiquitin E3 ligases regulating PD-1 stability have been reported, deubiquitinases governing PD-1 homeostasis to modulate tumor immunotherapy remain unknown. Here, we identify the ubiquitin-specific p...
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ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy
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TN_cdi_doaj_primary_oai_doaj_org_article_43341d084b874234849014855b8d8601
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_43341d084b874234849014855b8d8601
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-38605-3
