Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
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England: eLife Science Publications, Ltd
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English
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England: eLife Science Publications, Ltd
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GPCRs play critical roles in cell communication. Although GPCRs can form heteromers, their role in signaling remains elusive. Here we used rat metabotropic glutamate (mGlu) receptors as prototypical dimers to study the functional interaction between each subunit. mGluRs can form both constitutive homo- and heterodimers. Whereas both mGlu2 and mGlu4...
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Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer
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TN_cdi_doaj_primary_oai_doaj_org_article_435030e6c34648f2bd2b488461a946e3
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_435030e6c34648f2bd2b488461a946e3
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.26985
