DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
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Author / Creator
Wang, Pinhua , Sarkar, Sunayana , Zhang, Menghuan , Xiao, Tingting , Kong, Fenhua , Zhang, Zhe , Balasubramanian, Deepa , Jayaram, Nandan , Datta, Sayantan , He, Ruyu , Wu, Ping , Chao, Peng , Zhang, Ying , Washburn, Michael , Florens, Laurence A , Nagarkar-Jaiswal, Sonal , Jaiswal, Manish and Mohan, Man
Publisher
England: eLife Sciences Publications Ltd
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Language
English
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Publisher
England: eLife Sciences Publications Ltd
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Contents
DYRK1A, a ubiquitously expressed kinase
,
is linked to the dominant intellectual developmental disorder, microcephaly, and Down syndrome in humans. It regulates numerous cellular processes such as cell cycle, vesicle trafficking, and microtubule assembly. DYRK1A is a critical regulator of organ growth; however, how it regulates organ growth i...
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Full title
DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
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TN_cdi_doaj_primary_oai_doaj_org_article_4350b6428f4542ff8d1561e278254bd9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4350b6428f4542ff8d1561e278254bd9
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.88318
