Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without i...
Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors
About this item
Full title
Author / Creator
Barbon, Elena , Ayme, Gabriel , Mohamadi, Amel , Ottavi, Jean‐François , Kawecki, Charlotte , Casari, Caterina , Verhenne, Sebastien , Marmier, Solenne , van Wittenberghe, Laetitia , Charles, Severine , Collaud, Fanny , Denis, Cecile V , Christophe, Olivier D , Mingozzi, Federico and Lenting, Peter J
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Novel therapies for hemophilia, including non‐factor replacement and
in vivo
gene therapy, are showing promising results in the clinic, including for patients having a history of inhibitor development. Here, we propose a novel therapeutic approach for hemophilia based on llama‐derived single‐domain antibody fragments (sdAbs) able to restore h...
Alternative Titles
Full title
Single‐domain antibodies targeting antithrombin reduce bleeding in hemophilic mice with or without inhibitors
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4434607219fc41c0b6465b55049e9dff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4434607219fc41c0b6465b55049e9dff
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201911298
