Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK i...
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
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Author / Creator
Verginelli, Federica , Pisacane, Alberto , Gambardella, Gennaro , D’Ambrosio, Antonio , Candiello, Ermes , Ferrio, Marco , Panero, Mara , Casorzo, Laura , Benvenuti, Silvia , Cascardi, Eliano , Senetta, Rebecca , Geuna, Elena , Ballabio, Andrea , Montemurro, Filippo , Sapino, Anna , Comoglio, Paolo M. and Boccaccio, Carla
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cancers of unknown primary (CUPs), featuring metastatic dissemination in the absence of a primary tumor, are a biological enigma and a fatal disease. We propose that CUPs are a distinct, yet unrecognized, pathological entity originating from stem-like cells endowed with peculiar and shared properties. These cells can be isolated in vitro (agnospher...
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Full title
Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
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TN_cdi_doaj_primary_oai_doaj_org_article_4477922c33134d2989690669cbc5e8c0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4477922c33134d2989690669cbc5e8c0
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-22643-w
