Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
About this item
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Author / Creator
Rajendran, Jayasimman , Purhonen, Janne , Tegelberg, Saara , Smolander, Olli‐Pekka , Mörgelin, Matthias , Rozman, Jan , Gailus‐Durner, Valerie , Fuchs, Helmut , Hrabe de Angelis, Martin , Auvinen, Petri , Mervaala, Eero , Jacobs, Howard T , Szibor, Marten , Fellman, Vineta , Kallijärvi, Jukka , Faculty of Medicine , Medicinska fakulteten , Sektion III , Institutionen för kliniska vetenskaper, Lund , Lunds universitet , Department of Clinical Sciences, Lund , Paediatrics (Lund) , Lund University , Section III , Sektion V , Pediatrik, Lund , Section V , Infection Medicine (BMC) and Infektionsmedicin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Alternative oxidase (AOX) is a non‐mammalian enzyme that can bypass blockade of the complex III‐IV segment of the respiratory chain (RC). We crossed a
Ciona intestinalis
AOX transgene into RC complex III (cIII)‐deficient
Bcs1l
p.S78G
knock‐in mice, displaying multiple visceral manifestations and premature death. The homozygotes expre...
Alternative Titles
Full title
Alternative oxidase‐mediated respiration prevents lethal mitochondrial cardiomyopathy
Authors, Artists and Contributors
Author / Creator
Purhonen, Janne
Tegelberg, Saara
Smolander, Olli‐Pekka
Mörgelin, Matthias
Rozman, Jan
Gailus‐Durner, Valerie
Fuchs, Helmut
Hrabe de Angelis, Martin
Auvinen, Petri
Mervaala, Eero
Jacobs, Howard T
Szibor, Marten
Fellman, Vineta
Kallijärvi, Jukka
Faculty of Medicine
Medicinska fakulteten
Sektion III
Institutionen för kliniska vetenskaper, Lund
Lunds universitet
Department of Clinical Sciences, Lund
Paediatrics (Lund)
Lund University
Section III
Sektion V
Pediatrik, Lund
Section V
Infection Medicine (BMC)
Infektionsmedicin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_4482183c413e432b817baa4364affa08
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_4482183c413e432b817baa4364affa08
Other Identifiers
ISSN
1757-4676,1757-4684
E-ISSN
1757-4684
DOI
10.15252/emmm.201809456
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