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METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through...

METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_44abc2921c7e44cb86e9859eea78c7c6

METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence

About this item

Full title

METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence

Publisher

England: BioMed Central Ltd

Journal title

Journal of translational medicine, 2024-09, Vol.22 (1), p.865-17, Article 865

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

The increasing incidence of diabetes mellitus has established diabetic cataracts (DC) as a significant worldwide public health issue. The mechanisms underlying DC remain unknown, and effective prevention and treatment strategies are lacking. Accordingly, we aimed to explore the role and mechanism behind N6-methyladenosine (m6A) in DC progression.

Alternative Titles

Full title

METTL3-mediated m6A modification of SIRT1 mRNA affects the progression of diabetic cataracts through cellular autophagy and senescence

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_44abc2921c7e44cb86e9859eea78c7c6

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_44abc2921c7e44cb86e9859eea78c7c6

Other Identifiers

ISSN

1479-5876

E-ISSN

1479-5876

DOI

10.1186/s12967-024-05691-w

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