PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
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Author / Creator
Xie, Min , Yu, Yan , Kang, Rui , Zhu, Shan , Yang, Liangchun , Zeng, Ling , Sun, Xiaofang , Yang, Minghua , Billiar, Timothy R. , Wang, Haichao , Cao, Lizhi , Jiang, Jianxin and Tang, Daolin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis contributes to sepsis by modulating inflammasome...
Alternative Titles
Full title
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_44e902eea61c43bbab9d4975480e57e9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_44e902eea61c43bbab9d4975480e57e9
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms13280
