Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the com...
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
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The International League Against Epilepsy Consortium on Complex Epilepsies , International League Against Epilepsy Consortium on Complex Epilepsies , Abou-Khalil, Bassel , Auce, Pauls , Avbersek, Andreja , Bahlo, Melanie , Balding, David J. , Bast, Thomas , Baum, Larry , Becker, Albert J. , Becker, Felicitas , Berghuis, Bianca , Berkovic, Samuel F. , Boysen, Katja E. , Bradfield, Jonathan P. , Brody, Lawrence C. , Buono, Russell J. , Campbell, Ellen , Cascino, Gregory D. , Catarino, Claudia B. , Cavalleri, Gianpiero L. , Cherny, Stacey S. , Chinthapalli, Krishna , Coffey, Alison J. , Compston, Alastair , Coppola, Antonietta , Cossette, Patrick , Craig, John J. , de Haan, Gerrit-Jan , De Jonghe, Peter , de Kovel, Carolien G. F. , Delanty, Norman , Depondt, Chantal , Devinsky, Orrin , Dlugos, Dennis J. , Doherty, Colin P. , Elger, Christian E. , Eriksson, Johan G. , Ferraro, Thomas N. , Feucht, Martha , Francis, Ben , Franke, Andre , French, Jacqueline A. , Freytag, Saskia , Gaus, Verena , Geller, Eric B. , Gieger, Christian , Glauser, Tracy , Glynn, Simon , Goldstein, David B. , Gui, Hongsheng , Guo, Youling , Haas, Kevin F. , Hakonarson, Hakon , Hallmann, Kerstin , Haut, Sheryl , Heinzen, Erin L. , Helbig, Ingo , Hengsbach, Christian , Hjalgrim, Helle , Iacomino, Michele , Ingason, Andrés , Jamnadas-Khoda, Jennifer , Johnson, Michael R. , Kälviäinen, Reetta , Kantanen, Anne-Mari , Kasperavičiūte, Dalia , Kasteleijn-Nolst Trenite, Dorothee , Kirsch, Heidi E. , Knowlton, Robert C. , Koeleman, Bobby P. C. , Krause, Roland , Krenn, Martin , Kunz, Wolfram S. , Kuzniecky, Ruben , Kwan, Patrick , Lal, Dennis , Lau, Yu-Lung , Lehesjoki, Anna-Elina , Lerche, Holger , Leu, Costin , Lieb, Wolfgang , Lindhout, Dick , Lo, Warren D. , Lopes-Cendes, Iscia , Lowenstein, Daniel H. , Malovini, Alberto , Marson, Anthony G. , Mayer, Thomas , McCormack, Mark , Mills, James L. , Mirza, Nasir , Moerzinger, Martina , Møller, Rikke S. , Molloy, Anne M. , Muhle, Hiltrud , Newton, Mark , Ng, Ping-Wing , Nöthen, Markus M. , Nürnberg, Peter , O’Brien, Terence J. and Oliver, Karen L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which reveals 16 genome-wide significant loci, of which 11 are novel. Using various prioritization criteria, we pinpoint the 21 most lik...
Alternative Titles
Full title
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
Authors, Artists and Contributors
Author / Creator
International League Against Epilepsy Consortium on Complex Epilepsies
Abou-Khalil, Bassel
Auce, Pauls
Avbersek, Andreja
Bahlo, Melanie
Balding, David J.
Bast, Thomas
Baum, Larry
Becker, Albert J.
Becker, Felicitas
Berghuis, Bianca
Berkovic, Samuel F.
Boysen, Katja E.
Bradfield, Jonathan P.
Brody, Lawrence C.
Buono, Russell J.
Campbell, Ellen
Cascino, Gregory D.
Catarino, Claudia B.
Cavalleri, Gianpiero L.
Cherny, Stacey S.
Chinthapalli, Krishna
Coffey, Alison J.
Compston, Alastair
Coppola, Antonietta
Cossette, Patrick
Craig, John J.
de Haan, Gerrit-Jan
De Jonghe, Peter
de Kovel, Carolien G. F.
Delanty, Norman
Depondt, Chantal
Devinsky, Orrin
Dlugos, Dennis J.
Doherty, Colin P.
Elger, Christian E.
Eriksson, Johan G.
Ferraro, Thomas N.
Feucht, Martha
Francis, Ben
Franke, Andre
French, Jacqueline A.
Freytag, Saskia
Gaus, Verena
Geller, Eric B.
Gieger, Christian
Glauser, Tracy
Glynn, Simon
Goldstein, David B.
Gui, Hongsheng
Guo, Youling
Haas, Kevin F.
Hakonarson, Hakon
Hallmann, Kerstin
Haut, Sheryl
Heinzen, Erin L.
Helbig, Ingo
Hengsbach, Christian
Hjalgrim, Helle
Iacomino, Michele
Ingason, Andrés
Jamnadas-Khoda, Jennifer
Johnson, Michael R.
Kälviäinen, Reetta
Kantanen, Anne-Mari
Kasperavičiūte, Dalia
Kasteleijn-Nolst Trenite, Dorothee
Kirsch, Heidi E.
Knowlton, Robert C.
Koeleman, Bobby P. C.
Krause, Roland
Krenn, Martin
Kunz, Wolfram S.
Kuzniecky, Ruben
Kwan, Patrick
Lal, Dennis
Lau, Yu-Lung
Lehesjoki, Anna-Elina
Lerche, Holger
Leu, Costin
Lieb, Wolfgang
Lindhout, Dick
Lo, Warren D.
Lopes-Cendes, Iscia
Lowenstein, Daniel H.
Malovini, Alberto
Marson, Anthony G.
Mayer, Thomas
McCormack, Mark
Mills, James L.
Mirza, Nasir
Moerzinger, Martina
Møller, Rikke S.
Molloy, Anne M.
Muhle, Hiltrud
Newton, Mark
Ng, Ping-Wing
Nöthen, Markus M.
Nürnberg, Peter
O’Brien, Terence J.
Oliver, Karen L.
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_450148f9520f47a2a02f13cebc985c20
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_450148f9520f47a2a02f13cebc985c20
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07524-z
